Skeletal muscle fiber atrophy occurs in response to states of unloading such as during spaceflight (Adams et al. 2003) and ground-based analogues such as hind limb suspension and spaceflight in rodents (Caiozzo et al. 1994, 1996) and bedrest in humans (Adams et al. 2003). Unloading-induced atrophy appears to involve both components of the protein balance equation, which is defined as the ratio of protein synthesis rate divided by the protein degradation rate (synthesis/degradation rate) (Thomason and Booth 1990). When the degradation rate exceeds the synthesis rate, net protein loss (atrophy) occurs. While the equation is rather simple, the mechanisms are rather complex. The research emphasis during the past 10–15 years has focused heavily on understanding the upstream events regulating these protein processes.
Muscle Wasting in Space and Countermeasures
Handbook of Bioastronautics ; Chapter : 116 ; 181-196
2021-08-17
16 pages
Article/Chapter (Book)
Electronic Resource
English
British Library Online Contents | 1999
Countermeasures of Military Space Systems
NTIS | 1996
|Engineering Index Backfile | 1928
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