Effects of spaceflight on hypothalamic peptide systems controlling pituitary growth hormone dynamics
Effects of spaceflight on hypothalamic peptide systems controlling pituitary growth hormone dynamics
- New search for: Sawchenko, P. E.
- New search for: Arias, C.
- New search for: Krasnov, I.
- New search for: Grindeland, R. E.
- New search for: Vale, W.
- New search for: Sawchenko, P. E.
- New search for: Arias, C.
- New search for: Krasnov, I.
- New search for: Grindeland, R. E.
- New search for: Vale, W.
Possible effects of reduced gravity on central hypophysiotropic systems controlling growth hormone (GH) secretion were investigated in rats flown on Cosmos 1887 and 2044 biosatellites. Immunohistochemical (IHC)staining for the growth hormone-releasing factor (GRF), somatostatin (SS), and other hypothalamic hormones was performed on hypothalami obtained from rats. IHC analysis was complemented by quantitative in situ assessments of mRNAs encoding the precursors for these hormones. Data obtained suggest that exposure to microgravity causes a preferential reduction in GRF peptide and mRNA levels in hypophysiotropic neurons, which may contribute to impared GH secretion in animals subjected to spaceflight. Effects of weightlessness are not mimicked by hindlimb suspension in this system.
Document information
Effects of spaceflight on hypothalamic peptide systems controlling pituitary growth hormone dynamics
Journal of Applied Physiology, Supplement ; 73 , 2 Au
1992-08-01
Miscellaneous
No indication
English
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