Abstract Breast cancer is the most commonly occurring cancer in women and impacts around 2.1 million women each year. The drug treatment depends on the type of breast cancer and severity of disease. But, continuous use of drugs often leads to resistance and thus need arises for development of newer drugs. In order to find out the alternative treatment strategies, the breast cancer cells are analysed for their behaviour in different conditions. Microgravity is one such strategy currently being studied. Both cancerous and non-cancerous cells behave differently in absence of gravity. So, it could be speculated that microgravity might be a complementary tool for future cancer treatment and may open a new window for clinical cancer therapies. In this review, we summarise the effect of microgravity on breast cancer cells as well as anticancer drugs for breast cancer treatment, drugs in preclinical and clinical phases. We believe that this review will provide a comprehensive report on many aspects of breast cancer research and help to establish the therapeutic links between microgravity and breast cancer treatment.

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Highlights • Breast cancer is the most widely occurring cancer in women and overall ranks 5th in terms of cancer related mortalities. • Though a large number of drugs are available for treatment of breast cancer, prolong use of drugs leads to resistance and side effects. • In order to improve the efficacy of the drugs, new strategies like microgravity is being studied for future cancer treatment. • Microgravity or absence of gravity leads to certain changes in the normal and cancerous cells and can be exploited as a potential complementary tool for breast cancer treatment.