Compensatory postural adjustments in na oculus virtual reality environment and the risk of falling in Alzheimer’s disease

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Compensatory postural adjustments in na oculus virtual reality environment and the risk of falling in Alzheimer’s disease

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Gago, Miguel F. / Yelshyna, Darya / Bicho, Estela / Silva, Hélder / Rocha, Luís Alexandre Machado / Rodrigues, Maria Lurdes / Sousa, Nuno

Abstract

Background/Aims Alzheimer's disease (AD) patients have an impaired ability to quickly reweight central sensory dependence in response to unexpected body perturbations. Herein, we aim to study provoked compensatory postural adjustments (CPAs) in a conflicting sensory paradigm with unpredictable visual displacements using virtual reality goggles. Methods We used kinematic time-frequency analyses of two frequency bands: a low-frequency band (LB; 0.3-1.5 Hz; mechanical strategy) and a high-frequency band (HB; 1.5-3.5 Hz; cognitive strategy). We enrolled 19 healthy subjects (controls) and 21 AD patients, divided according to their previous history of falls. Results The AD faller group presented higher-power LB CPAs, reflecting their worse inherent postural stability. The AD patients had a time lag in their HB CPA reaction. Conclusion The slower reaction by CPA in AD may be a reflection of different cognitive resources including body schema self-perception, visual motion, depth perception, or a different state of fear and/or anxiety. ; The Centro ALGORITMI was funded by the FP7 Marie Curie ITN Neural Engineering Transformative Technologies (NETT) project. The authors have no conflicts of interest to report. ; info:eu-repo/semantics/publishedVersion

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Title :

Compensatory postural adjustments in na oculus virtual reality environment and the risk of falling in Alzheimer’s disease

Contributors:

Gago, Miguel F. (author) / Yelshyna, Darya (author) / Bicho, Estela (author) / Silva, Hélder (author) / Rocha, Luís Alexandre Machado (author) / Rodrigues, Maria Lurdes (author) / Sousa, Nuno (author)

Publication date :

2016-01-25

Remarks:

doi:10.1159/000447124

DOI :

https://doi.org/10.1159/000447124

Type of media :

Article (Journal)

Type of material :

Electronic Resource

Language :

English