In this paper a modification of the traditional section interconnection design was presented with the purpose to effectively attenuate the transfer of structure-borne sound between two fuselage sections. To evaluate the vibro-acoustic performance of the modified interconnection, three models of different complexity have been investigated:The analysis of the beam model showed, that a significant attenuation of structure-borne sound waves can be achieved and that the frame geometry is the primary parameter in the isolation performance of the interconnection. In the plate model analysis, measurements and simulations showed the same trend, both confirming that the modified interconnection design leads to a signifcant transmission loss increase. However, to minimize the differences between the experimental and the numerical model in future investigations, both need to be refined. Finally, the simulations on the full-scale fuselage model showed, that the transmission loss between the sections is similarly improved, when the modified interconnection design is applied to a more realistic aircraft structure. The studies in this paper show, that the proposed section interconnection design promises a significant reduction of structure-borne sound transfer between two fuselage sections, especially in the acoustically challenging low-frequency regime. The analyses performed in this work involve only vibro-acoustical aspects and simplified geometries. The next steps in the evaluation of the modified interconnection design would include a more complex fuselage structure with frames, floor beams etc. and an evaluation of the influence of an asymmetric interconnection design to avoid potential resonance cases. Also, an investigation of the fluid-structure-coupling inside and outside of the fuselage and an assessment of the static and fatigue strength properties of the design should be performed in further studies.