The design of low vibrating and low noise engines is still a challenging task due to contrary demands like increasing use of light weight materials and tighter limits of admissible stress and strain. To shorten the entire design process with pre-optimised prototypes the simulation of engine and power unit vibration and structure-borne noise (surface velocity levels) as well as noise radiation becomes more and more a standard application. The typical approach is the well known methodology of multibody dynamic with flexible bodies and the transient analysis in time domain under running conditions. During the last years the dynamic multi-body simulation has reached a certain level or accuracy and has proven to be a practical and efficient method for solving of complex engine dynamic problems. Beside the improvement of software functionality to cover all operating and loading conditions including all important excitations from the cranktrain and timing drive, the target is to better integrale the necessary combined simulation methodologies to reduce the overall analysis time (time of entire workflow). For an applicable usage of such simulation, extensive simulation measurement comparison is necessary for validation of models and methodology and the knowledge about absolute as well as relative simulation result quality is necessary for implementation of such simulation procedures into the engine development process where no experimental data is available. Separate method development projects for simulation-measurement comparison are useful to investigate in the quality and sensitivity of results. The prediction and comparison has to be done for the entire speed range and main loading conditions. This results in a large amount of simulation data for complex results as mount vibrations, structure borne noise and sound radiation. Therefore intelligent, compact and instructive result evaluation methods are required to enable a fast and clear overview. The current paper focuses on this comparison between simulation and measurement to support the engine development for mount vibrations, structure and air borne noise, the achievable accuracy and the result evaluation. Cranktrain, piston secondary motion and excitation from the entire timing drive including detailed model of chain, belt or gear train have to be considered. As joint definitions between the connected bodies play an important role for accuracy and overall simulation time, different modelling approaches for most important joints as engine mounts, main bearings and piston-liner contact are discussed.