Helium-ion-induced human cataractogenesis

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Helium-ion-induced human cataractogenesis

Blakely, E. A. / Daftari, I. K. / Meecham, W. J. / Alonso, L. C. / Collier, J. M. / Kroll, S. M. / Gillette, E. L. / Lee, A. C. / Lett, J. T. / Cox, A. B.

Abstract

Retrospective and ongoing analyses of clinical records from 347 primary intraocular melanoman patients treated with helium ions at Lawrence Berkeley Laboratory (LBL) will allow examination of the exposure-response data for human cataract; which is a complication of the therapy from incidental exposure of the lens. Direct particle beam traversal of at least a portion of the lens usually is unavoidable in treatment of posterior intraocular tumors. The precise treatment planned for each patient permits quantitative assessment of the lenticular dose and its radiation quality. We are reporting our preliminary results on the development of helium-ion-induced lens opacifications and cataracts in 54 of these patients who had 10% or less of their lens in the treatment field. We believe these studies will be relevant to estimating the human risk for cataract in space flight.

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Document information

Title :

Helium-ion-induced human cataractogenesis

Contributors:

Blakely, E. A. (author) / Daftari, I. K. (author) / Meecham, W. J. (author) / Alonso, L. C. (author) / Collier, J. M. (author) / Kroll, S. M. (author) / Gillette, E. L. (author) / Lee, A. C. (author) / Lett, J. T. (author) / Cox, A. B. (author)

Published in:

Life Sciences and Space Research 25 (2) Radiation Biology: Topical Meeting of the COSPAR Interdisciplinary Scientific Commission F of the COSPAR 29th Plenary Meeting, Washington, DC, Aug. 28-Sep. 5, 1 ; 14 , 10

Publication date :

1994-10-01

ISSN :

0273-1177

Type of media :

Miscellaneous

Type of material :

No indication

Language :

English