This thesis considers control systems governed by autonomous decision-makers and humans. We formalise and compute low-complex control policies with applications to large-scale systems, and propose human interaction models for controllers to compute interaction-aware decisions. In the first part of the thesis, we consider complexity-aware decision-making, formalising the complexity of control policies and constructing algorithms that compute low-complexity control policies. More precisely, first, we consider large-scale control systems given by hierarchical finite state machines (HFSMs) and present a planning algorithm for such systems that exploits the hierarchy to compute optimal policies efficiently. The algorithm can also handle changes in the system with ease. We prove these properties and conduct simulations on HFSMs with up to 2 million states, including a robot application, where our algorithm outperforms both Dijkstra's algorithm and Contraction Hierarchies. Second, we present a planning objective for control systems modelled as finite state machines yielding an explicit trade-off between a policy's performance and complexity. We consider Kolmogorov complexity since it captures the ultimate compression of an object on a universal Turing machine. We prove that this trade-off is hard to optimise in the sense that dynamic programming is infeasible. Nonetheless, we present two heuristic algorithms obtaining low-complexity policies and evaluate the algorithms on a simple navigation task for a mobile robot, where we obtain low-complexity policies that concur with intuition. In the second part of the thesis, we consider human-in-the-loop systems and predict human decision-making in such systems. First, we look at how the interaction between a robot and a human in a control system can be predicted using game theory, focusing on an autonomous truck platoon interacting with a human-driven car. The interaction is modelled as a hierarchical dynamic game, where the hierarchical decomposition is temporal with a ...