NASA Kennedy Space Center (KSC) was established as the gateway to exploring beyond earth. Since the establishment of KSC in December 1963, the Center has been critical in the execution of the United States of Americas bold mission to send astronauts beyond the grasp of the terra firma. On May 25, 1961, a few weeks after a Soviet cosmonaut became the first person to fly in space, President John F. Kennedy laid out the ambitious goal of landing a man on the moon and returning him safely to the Earth by the end of the decade. The resultant Apollo program was massive endeavor, driven by the Cold War Space Race, and supported with a robust budget. The Apollo program consisted of 18 launches from newly developed infrastructure, including 12 manned missions and six lunar landings, ending with Apollo 17 that launched on December 7, 1972. Continuing to use this infrastructure, the Skylab program launched four missions. During the Skylab program, KSC infrastructure was redesigned to meet the needs of the Space Shuttle program, which launched its first vehicle (STS-1) on April 12, 1981. The Space Shuttle required significant modifications to the Apollo launch pads and assembly facilities, as well as new infrastructure, such as Orbiter and Payload Processing Facilities, as well as the Shuttle Landing Facility. The Space Shuttle was a workhorse that supported many satellite deployments, but was key for the construction and maintenance of the International Space Station, which required additional facilities at KSC to support processing of the flight hardware. After reaching the new Millennium, United States policymakers searched for new ways to reduce the cost of space exploration. The Constellation Program was initiated in 2005 with a goal of providing a crewed lunar landing with a much smaller budget. The very successful Space Shuttle made its last launch on July 8, 2011, after 135 missions. In the subsequent years, KSC continues to evolve, and this paper will address past and future efforts of the transformation of the KSC Apollo and Space Shuttle heritage infrastructure into a more versatile, multi-user spaceport. The paper will also discuss the US Congressional and NASA initiatives for developing and supporting multiple commercial partners, while simultaneously supporting NASAs human exploration initiative, consisting of Space Launch System (SLS), Orion spacecraft and associated ground launch systems. In addition, the paper explains the approach with examples for NASA KSC to leverage new technologies and innovative capabilities developed to reduce the cost to individual users.