The presence and absence of periplasmic rings in bacterial flagellar motors correlates with stator type.

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The presence and absence of periplasmic rings in bacterial flagellar motors correlates with stator type.

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Kaplan, M / Ghosal, D / Subramanian, P / Oikonomou, CM / Kjaer, A / Pirbadian, S / Ortega, DR / Briegel, A / El-Naggar, MY / Jensen, GJ

Abstract

The bacterial flagellar motor, a cell-envelope-embedded macromolecular machine that functions as a cellular propeller, exhibits significant structural variability between species. Different torque-generating stator modules allow motors to operate in different pH, salt or viscosity levels. How such diversity evolved is unknown. Here, we use electron cryo-tomography to determine the in situ macromolecular structures of three Gammaproteobacteria motors: Legionella pneumophila, Pseudomonas aeruginosa, and Shewanella oneidensis, providing the first views of intact motors with dual stator systems. Complementing our imaging with bioinformatics analysis, we find a correlation between the motor's stator system and its structural elaboration. Motors with a single H+-driven stator have only the core periplasmic P- and L-rings; those with dual H+-driven stators have an elaborated P-ring; and motors with Na+ or Na+/H+-driven stators have both their P- and L-rings embellished. Our results suggest an evolution of structural elaboration that may have enabled pathogenic bacteria to colonize higher-viscosity environments in animal hosts.

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Titel :

The presence and absence of periplasmic rings in bacterial flagellar motors correlates with stator type.

Beteiligte:

Kaplan, M (Autor:in) / Ghosal, D (Autor:in) / Subramanian, P (Autor:in) / Oikonomou, CM (Autor:in) / Kjaer, A (Autor:in) / Pirbadian, S (Autor:in) / Ortega, DR (Autor:in) / Briegel, A (Autor:in) / El-Naggar, MY (Autor:in) / Jensen, GJ (Autor:in)

Erscheinungsdatum :

2019-01-16

Medientyp :

Aufsatz (Zeitschrift)

Format :

Elektronische Ressource

Sprache :

Englisch

Klassifikation :

DDC:

629

Lizenzbestimmungen :

https://creativecommons.org/licenses/by/4.0

The presence and absence of periplasmic rings in bacterial flagellar motors correlates with stator type.

The presence and absence of periplasmic rings in bacterial flagellar motors correlates with stator type.

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