The role of nucleotides in augmentation of lymphocyte locomotion: Adaptional countermeasure development in microgravity analog environments

Sie sind hier: Homepage > Suche

The role of nucleotides in augmentation of lymphocyte locomotion: Adaptional countermeasure development in microgravity analog environments

Sundaresan, Alamelu / Kulkarni, Anil D. / Yamauchi, Keiko / Pellis, Neal R.

Space travel and long-term space residence such as envisaged in the exploration era implicates burdens on the immune system. An optimal immune response is required to counteract and withstand exposure to pathogens. Countermeasure development is an important avenue in space research especially for long-term space exploration. Microgravity exposure causes detrimental effects in lymphocyte functions which may impair immune response. Impaired lymphocyte function can be remedied by bypassing cell membrane events. This is done by using compounds such as phorbol myristate acetate (PMA). Since activation in mouse splenocytes was augmented using nucleotides, it was essential to observe their effects on human lymphocyte locomotion. A nucleotide/nucleoside (NT/NT) mixture from Otsuka Pharmaceuticals (Naruto, Japan) was used at recommended doses. In lymphocytes cultured in modeled microgravity, the NT/NT mixture used orchestrated locomotion recovery by more than 87%, similar to the response documented with PMA in lymphocytes. Both 12 micro M and 120 micro M doses worked similarly. These are preliminary results leading to the possible use of the NT/NT mixture to mitigate immune suppression in microgravity. More studies in this direction are required to delineate the role of NT/NT on the immune response in microgravity.

Zugriff

Zugriff über TIB

Verfügbarkeit in meiner Bibliothek prüfen

Bestellung bei Subito €

Exportieren, teilen und zitieren

Dokumentinformationen

Titel :

The role of nucleotides in augmentation of lymphocyte locomotion: Adaptional countermeasure development in microgravity analog environments

Weitere Titelangaben:

Die Rolle von Nukleotiden bei der Verstärkung der Lymphozyten-Beweglichkeit: Entwicklung adaptiver Gegenmaßnahmen in Mikrogravitäts-analogen Umgebungen

Beteiligte:

Sundaresan, Alamelu (Autor:in) / Kulkarni, Anil D. (Autor:in) / Yamauchi, Keiko (Autor:in) / Pellis, Neal R. (Autor:in)

Erschienen in:

ELGRA, Symposium of the European Low Gravity Research Association, 2005 ; 247-249

Microgravity Science and Technology ; 18 , 3/4

Erscheinungsdatum :

2006

Format / Umfang :

3 Seiten, 3 Bilder, 9 Quellen

ISSN :

0938-0108

DOI :