In late 2022, NASA’s SLS (Space Launch System) super heavy-lift rocket launched for the first time. Artemis I sent an uncrewed Orion spacecraft on a 25.5-day round-trip mission to lunar orbit. The near-perfect performance laid the groundwork for the next flights and for NASA’s return of humans to the Moon. The SLS team is now preparing for the launch of Artemis II, which will be the first launch of astronauts to cislunar space since Apollo 17 in December 1972. In addition to preparations on the Artemis II launch vehicle, significant progress is being made on the hardware and software for future flights. Artemis II will include a test of a new military-grade GPS system, which will be fully utilized on Artemis III. Progress is also being made on the exploration upper stage (EUS) for the Block 1B SLS variant, which will debut on Artemis IV. New production RS-25 liquid-propellant engines will be used beginning with Artemis V. These new engines, which are in a final qualification test firing program at the time of writing, realize a cost savings of at least 30 percent and reduced production time due to streamlined manufacturing and advances in technology, including additive manufacturing. The evolved solid rocket boosters, which will debut on Artemis IX as part of the Block 2 variant, are in development now. In addition to propulsion updates, each variant of SLS maintains payload configuration flexibility and can fly crew-only, cargo-only, and crew-cargo combinations. This adaptability ensures that SLS, with its significant mass and volume capability – including the ability to launch large co-manifested payloads with Orion directly to trans-lunar injection (TLI) – can support the country’s most ambitious missions. Results from the Artemis I mission, as well as progress to the next flights and SLS variants, will be covered in the paper and presentation.