The SLS Artemis I launch vehicle is the first of several planned Artemis launch vehicles, with a number of design differences from earlier NASA missions that incur liftoff debris risk to the mission. As a test vehicle, the Artemis I hardware also endured environments and tests not planned for future missions, which led to several additional factors contributing to an evolving liftoff debris risk to the SLS vehicle. This paper will summarize these risk factors and address the processes used to evaluate and communicate the risks to support a successful Artemis I launch. It will discuss how the evolving risks that were quantified and evaluated by a Cross-Program team of debris Subject Matter Experts to mitigate liftoff debris hazards and communicate updated risk to the SLS vehicle. This process was performed through the inaugural use of an SLS debris day-of-launch (DOL) standard operating procedure that will be used for subsequent Artemis missions. This paper addresses the risk of liftoff debris, debris released by the vehicle or from the launch pad during liftoff through vehicle tower clear. Expected liftoff debris is well understood from previous NASA programs’ experience and from tests of materials, processes and functions that are known to release liftoff debris. These expected sources were assessed and cleared well ahead of launch day. However, given the ever-changing schedules and environments, processes were in place to evaluate any additional potential liftoff debris risks identified during launch countdown. Although many of the Artemis vehicle hardware components are similar to those on the NASA Shuttle Program, there are important differences in the architecture of the Artemis I vehicle which require new assessments of liftoff debris risk for the Artemis missions. The more favorable Artemis crew module location and surfaces are far less vulnerable to debris impacts; however, the longer vehicle can result in higher liftoff debris impact energies to those components on the aft end of the vehicle. Additionally, the positional change of the RS-25 liquid engines to nearer the Booster nozzle exit plane along with the change in Booster throat plug design is a disadvantage to the overall liftoff debris risk which resulted in additional test and analysis efforts for evaluating the integrated vehicle debris risk. In spite of the comprehensive tests and analyses of Artemis I expected liftoff debris, a number of additional tests/processes were completed prior to the Artemis I mission that were required to support a complete understanding of a new launch vehicle, but increased the risk of releasing liftoff debris. The hardware endured several additional cryogenic loading cycles, including the Green Run tests at Stennis Space Center, Wet Dress Rehearsals at Kennedy Space Center, and multiple launch attempts. Each of these cycles induced stresses in the thermal protection system (TPS) materials, increasing the risk of damage to and release of the TPS. Additionally, induced and weather environmental factors that could increase the likelihood of debris release were significant. Vibrations and stresses in the TPS were induced by a required roll-back to the Vehicle Assembly Building before Hurricane Ian to protect the vehicle from damage by high winds. Wind damage and potential internal stresses to several outer mold line materials on the integrated SLS vehicle and mobile launcher were caused by weathering Hurricane Nicole at Pad 39B the week before launch. A thorough imagery scan of the vehicle was performed after each event and the damage observed was repaired, removed, or assessed and the risk to the mission evaluated. Mitigation of debris risk can occur by tests and analyses to show debris impacted components as damage tolerant, by new/improved processes for prevention of debris availability, or redesign. Risk mitigation processes for Artemis I-specific liftoff debris events and the development and use of the SLS debris day of launch (DOL) procedures that will be used for subsequent Artemis missions will be described.