The Johns Hopkins University Applied Physics Laboratory (JHU/APL) is leading the NASA funded Interstellar Probe study to explore the “Very Local” interstellar medium. To perform this exploration the mission will be required to last at least 50 years in regions of space where solar power is no longer practical. Additionally, several new studies for the National Academies’ Planetary Science and Astrobiology Decadal Survey are planning missions lasting 20-35 years. The Decadal Survey is used to build consensus on priority of national science goals. These proposed missions are inconsistent with the NASA’s current Radioisotope Power Systems (RPS) life requirement of 14 years (flight). Paramount to these proposed long-duration missions are questions about the longevity of such a mission. Evidence exists that space-borne Radioisotope Power Systems can indeed last a long time. LES-9, Voyager I, and Voyager II are over 40 years old, LES-8, Pioneer 10, and Pioneer 11 lasted 28, 30, and 22 years, respectively, and New Horizons is still active 15 years after launch. This paper explores the need for RPS designs that are intended to last much longer than the current requirement of 14 years (17 years after fueling) and explores the historical record for actual vs design lifetimes to show the feasibility of building long lasting RPS. We also exercise a current RTG performance model of the General-Purpose Heat Source RTG using the JPL Lifetime Performance Prediction (LPP) tool to make top-level inferences about power output at end-of-mission, and discusses how reliability engineering and testing methods can be brought to bear to increase confidence in delivering sufficient power at end-of-mission.