A piloted simulation that studied the handling qualities for a precision lunar landing task from final approach to touchdown is presented. A vehicle model based on NASA's Altair Lunar Lander was used to explore the design space around the nominal vehicle configuration to determine which combination of factors provides satisfactory pilot-vehicle performance and workload; details of the control and propulsion systems not available for that vehicle were derived from Apollo Lunar Module data. The experiment was conducted on a large motion base simulator. Eight Space Shuttle and Apollo pilot astronauts and three NASA test pilots served as evaluation pilots, providing Cooper-Harper ratings, Task Load Index ratings and qualitative comments. Each pilot flew seven combinations of control response types and three sets of displays, including two varieties of guidance and a nonguided approach. The response types included Rate Command with Attitude Hold, which was used in the original Apollo Moon landings, a Velocity Increment Command response type designed for up-and-away flight, three response types designed specifically for the vertical descent portion of the trajectory, and combinations of these. It was found that Velocity Increment Command significantly improved handling qualities when compared with the baseline Apollo design, receiving predominantly Level 1 ratings. This response type could be flown with or without explicit guidance cues, something that was very difficult with the baseline design, and resulted in approximately equivalent touchdown accuracies and propellant burn as the baseline response type. The response types designed to be used exclusively in the vertical descent portion of the trajectory did not improve handling qualities.