Excitement is building for the first launch of NASA’s Space Launch System (SLS), a unique exploration asset for the agency’s Artemis lunar program as well as for a new generation of science missions. SLS is designed for an array of missions beyond Earth’s orbit. The flexible system, which can be configured for Orion, cargo or Orion with co-manifested payload missions, offers high escape velocities to send more mass to deep space destinations. When configured with an 8.4 m-diameter fairing, SLS offers unmatched payload volume for human exploration and science missions. The initial Block 1 variant will insert at least 26 metric tons (t) to trans-lunar injection (TLI) and the more powerful Block 1B vehicle will launch 34-37 t to TLI using a new-development upper stage. Much of the initial SLS Block 1 vehicle is complete, including the upper stage and payload section, the core stage, engines and the solid rocket boosters. The first mission, Artemis I, launching from modernized and upgraded facilities at Kennedy Space Center (KSC), will be an uncrewed test flight of SLS, Orion and ground processing, with a primary objective of testing Orion’s heat shield at lunar re-entry velocity. Artemis I will have accommodations for 13 6U CubeSat payloads. These CubeSat missions will be deployed along the upper stage disposal trajectory after Orion separates from the vehicle. A rare opportunity for CubeSats to be deployed beyond low Earth orbit (LEO), Artemis I CubeSat missions range from searching for hydrogen and other volatiles on the lunar South Pole to studying the acceleration mechanisms of solar and interplanetary particles from a heliocentric trajectory. With manufacturing of the initial vehicle complete, fabrication and procurement is progressing for the second flight of SLS and Orion, Artemis II. Also an SLS Block 1 and Orion flight launching from KSC, Artemis II will mark the return of American astronauts to deep space with a lunar flyby-free return trajectory mission. With the Artemis III flight, NASA has the goal to land the first woman and the next man on the Moon. Infrastructure beyond SLS will be required for this effort, including elements of the lunar Gateway as well as lunar rovers, landers and additional commercially supplied launch services. SLS, as the only vehicle with the capability to lift 26 t of mass to TLI in its initial Block 1 variant, will remain a key component of this new-era exploration program. Future variants – Block 1B and Block 2 –will lift 34-45 t to TLI. This paper will discuss the status of testing and integration for the Artemis I vehicle, manufacturing progress for the second vehicle and the manifest outlook for primary, co-manifested and secondary payloads in the current deep space exploration environment.