Neuroimmune response and sleep studies after whole body irradiation with high-LET particles

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Neuroimmune response and sleep studies after whole body irradiation with high-LET particles

Marquette, C. / Mathieu, J. / Bertho, J.-M. / Galonnier, M. / Wysoki, J. / Maubert, C. / Balanzat, E. / Gerbin, R. / Aigueperse, J. / Clarençon, D.

Abstract

AbstractIn order to investigate the biological effects of galactic rays on astronaut cerebral functions after space flight, mice were exposed to different heavy ions (HZE) in whole-body conditions at doses comparable to the galactic flux: ¹²C, ¹⁶O and ²⁰Ne (95MeV/u, at 42–76mGy). Animals were also exposed to 42mGy of ⁶⁰Co radiation for comparison with HZE. The neuroimmune response, evaluated by interleukin-1 (IL-1) measurement, showed that this cytokine was produced 3h after irradiation by ¹⁶O or ⁶⁰Co. In contrast, neither ¹²C (56.7mGy) nor ²⁰Ne (76mGy) induced IL-1 production. However, immunohistochemical staining of ¹²C-irradiated mouse brain tissue showed 2months later a marked inflammatory reaction in the hippocampus and a diffuse response in parenchyma. Sleep studies were realized before and after exposure to 42mGy of ¹⁶O and 76mGy of ²⁰Ne: only the ²⁰Ne radiation displayed a small effect. A slight decrease in paradoxical sleep, corresponding to a reduction in the number of episodes of paradoxical sleep, was manifested between 8 and 22days after exposure. Exposure to ¹²C and ¹⁶O induced no changes either in cellularity of spleen or thymus, or in caspase 3 activity (as much as four months after irradiation). Taken together, these data indicate that the CNS could be sensitive to heavy ions and that responses to HZE impact depend on the nature of the particle, the dose threshold and the time delay to develop biological processes. Differences in responses to different HZE highlight the complex biological phenomena to which astronauts are submitted during space flight.

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Dokumentinformationen

Titel :

Neuroimmune response and sleep studies after whole body irradiation with high-LET particles

Beteiligte:

Marquette, C. (Autor:in) / Mathieu, J. (Autor:in) / Bertho, J.-M. (Autor:in) / Galonnier, M. (Autor:in) / Wysoki, J. (Autor:in) / Maubert, C. (Autor:in) / Balanzat, E. (Autor:in) / Gerbin, R. (Autor:in) / Aigueperse, J. (Autor:in) / Clarençon, D. (Autor:in)

Erschienen in:

Advances in Space Research ; 44 , 8 ; 934-941

Erscheinungsdatum :

2009-01-05

Format / Umfang :

8 pages

ISSN :

0273-1177

DOI :

https://doi.org/10.1016/j.asr.2009.01.040

Medientyp :

Aufsatz (Zeitschrift)