DNA double strand breaks (DSBs) are repaired in eukaryotes by one of several cellular mechanisms. The decision-making process controlling DSB repair takes place at the step of DNA end resection, the nucleolytic processing of DNA ends, which generates singlestranded DNA overhangs. Dependent on the length of the overhang, a corresponding DSB repair mechanism is engaged. Interestingly, nucleosomes—the fundamental unit of chromatin—influence the activity of resection nucleases and nucleosome remodelers have emerged as key regulators of DSB repair. Nucleosome remodelers share a common enzymatic mechanism, but for global genome organization specific remodelers have been shown to exert distinct activities. Specifically, different remodelers have been found to slide and evict, position or edit nucleosomes. It is an open question whether the same remodelers exert the same function also in the context of DSBs. Here, we will review recent advances in our understanding of nucleosome remodelers at DSBs: to what extent nucleosome sliding, eviction, positioning and editing can be observed at DSBs and how these activities affect the DSB repair decision.
DNA Double Strand Break Repair and Its Control by Nucleosome Remodeling
Frontiers in Genetics ; 12 ; 821543
2022-01-12
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
ISWI is a nucleosome remodeling, spacing and sliding factor
British Library Conference Proceedings | 1999
|DNA Double Strand Break Production and Rejoining in V79 Cells Irradiated with Light Ions
Online Contents | 1996
|DNA Double Strand Break Production and Rejoining in V79 Cells Irradiated with Light Ions
British Library Conference Proceedings | 1995
|Repair of DNA Double-Strand Breaks and its Effect on RBE
Online Contents | 1994
|Repair of DNA double-strand breaks and its effect on RBE
Elsevier | 1994
|