Stable grasping is essential for assistive robots aiding individuals with severe motor– sensory disabilities in their everyday lives. Slip detection can prevent unstably grasped objects from falling out of the gripper and causing accidents. Recent research on slip detection focuses on tactile sensing; however, not every robot arm can be equipped with such sensors. In this paper, we propose a slip detection method solely based on data collected by a RealSense D435 Red Green Blue-Depth (RGBd) camera. By utilizing Farneback optical flow (OF) to estimate the motion field of the grasped object relative to the gripper, while also removing potential background noise, the algorithm can perform in a multitude of environments. The algorithm was evaluated on a dataset of 28 daily objects that were lifted 30 times each, resulting in a total of 840 frame sequences. Our proposed slip detection method achieves an accuracy of up to 82.38% and a recall of up to 87.14%, which is comparable to state-of-the-art approaches when only using camera data. When excluding objects for which movements are challenging for vision-based methods to detect, such as untextured or transparent objects, the proposed method performs even better, with an accuracy of up to 87.19% and a recall of up to 95.09%. ; Stable grasping is essential for assistive robots aiding individuals with severe motor–sensory disabilities in their everyday lives. Slip detection can prevent unstably grasped objects from falling out of the gripper and causing accidents. Recent research on slip detection focuses on tactile sensing; however, not every robot arm can be equipped with such sensors. In this paper, we propose a slip detection method solely based on data collected by a RealSense D435 Red Green Blue-Depth (RGBd) camera. By utilizing Farneback optical flow (OF) to estimate the motion field of the grasped object relative to the gripper, while also removing potential background noise, the algorithm can perform in a multitude of environments. The algorithm was evaluated ...